When scientists broke the human genome 2003 – Setting your complete genetic code of a human being – many individuals expected to unlock the secrets of the disease. But Genetics Explained only 10 % of the danger. The remaining 90 % of the environment lies within the environment – and the eating regimen plays an enormous part.
Around the world, there may be a poor eating regimen Association Up to 1 in five adults aged 25 or older. In Europe, it’s calculated About half All cardiovascular deaths.
But despite many years of recommendation about fat, salt or sugar, obesity and dietary disease cutting Waking up. Clearly, Something is missing The way we expect of food.
For years, nutrition has often been produced in easy terms: food and nutrients because the body's constructing blocks. About protein, carbohydrate, fat and vitamins – about 150 known chemicals Overall – has dominated the image. But scientists now guess that our eating regimen actually provides greater than 26,000 Compounds, most of them are still unnecessary.
This is the place where astronomy provides a useful comparison. Astronomers know that the work of the dark matter ends 27 % of the universe. It doesn’t exclude the sunshine and doesn’t reflect the sunshine, and subsequently it can’t be seen directly, but its gravity effects show that it must exist.
Nutrition Science has an analogous face. In the case of research, most chemicals are hidden to us in food. We eat them each day, but we have now little guess what they do.
Some experts confer with these unknown molecules “Nutritional Dark Media”. It is a reminder that just as cosmos is filled with invisible forces, our eating regimen is filled with hidden chemistry.
When researchers analyze the disease, they see a big selection of food, though no association can often be much like known molecules. This is a dark matter of nutrition – the compounds we eat each day but haven’t been mapped or studied. Some can encourage health, but others may increase the danger of disease. The challenge is thought what’s.
Foodomix
Field of Foodomix That's exactly what. It collects genomics (the role of genes), proteomx (protein), metabolomics (cell activity) and neutrinomics (interaction of genes and eating regimen).
These approaches are starting to indicate how the eating regimen intensifies greater than calories and vitamins with the body.
For example, take the Mediterranean eating regimen (fruits, vegetables, whole grains, beans, nuts, olive oil and fish), which is thought about Reduce The risk of heart disease.
But why does it work? A gesture is in a molecule called TMAO (trimethylamine n-oxide)Gut bacteria in beef and eggs produce metabolized compounds. High levels of TMAOs increase the danger of heart disease. But GarlicFor example, incorporates material that stops its production. This is an example of how eating regimen can discover the balance between health and loss.
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Gut bacteria Also play a very important role. When compounds reach the colon, germs convert them into recent chemicals that may affect inflammation, immunity and metabolism.
For example, Ellagic acid – found in several fruits and nuts – converted through gut bacteria urolithins. It is a gaggle of natural compounds that help keep our microorria (body energy factories) healthy.
This shows how the food is a posh web of communicating chemicals. One compound can affect many biological mechanisms, which can lead to many others. Diet may even turn or shut down genes Epagnitics – Changes to gene activity that don’t change DNA itself.
History has provided excellent examples of this. For example, during World War II, there have been children born within the Netherlands within the Netherlands. More likely To promote heart disease, later type 2 diabetes and schizophrenia in life. Decading many years later, scientists found what their moms ate their genes activity – or not ate – while getting pregnant.
Maping of food universe
Projects corresponding to projects Foodom Project Now they try to list this hidden chemical universe. More than 130,000 molecules Food compounds have already been listed in connecting the strategy of human protein, gut microbes and diseases. The purpose is to how the eating regimen interacts with the body, and to discover which unoccupation is basically necessary for health.
It is hoped that by understanding the dark matter of nutrition, we are able to answer questions which have long frustrated nutrition science. Why do some foods work for some people but not others? Why do foods sometimes prevent the disease, and sometimes promote? Which food molecules will be used for the preparation of latest drugs, or recent foods?
We are still at first. But the message is evident – food on our plate is just not just calories and nutrients, but in addition a large chemical scenario that we are only charting. Just because the mapping of the dark matter of the dark matter is changing our theory concerning the universe, so how can we eat the darkest dietary substance, how we treat the disease and the way we expect of health ourselves.